Established on October 16, 1961, the Roman Catholic Diocese of San Angelo, Texas, encompasses some 37,433 square miles. It comprises 29 counties in West and Central Texas: Andrews, Brown, Callahan, Coke, Coleman, Concho, Crane, Crockett, Ector, Glasscock, Howard, Irion, Kimble, Martin, McCulloch, Menard, Midland, Mitchell, Nolan, Pecos, Reagan, Runnels, Schleicher, Sterling, Sutton, Taylor, Terrell, Tom Green and Upton.
Major cities located in the diocese are: Abilene, Big Spring, Brownwood, Fort Stockton, Midland, Odessa, San Angelo, and Sweetwater.